MyBioSource.com's Rabbit Anti-DOG1 Antibody is a Rabbit monoclonal antibody. The Rabbit Anti-DOG1 Antibody was generated using ANO1, and Anoctamin 1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to test. Immunoreactivity for DOG-1 has been reported in 97.8 % of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including platelet-derived growth factor Receptor alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%